After Week 5, there are currently 58 undefeated teams left in the state of North Carolina. Below is the list of teams who have not yet suffered a loss and their Week 6 opponent.
| 4A - 13 Teams | Next Game | |
| East Forsyth | 4-0 | Home vs East Forsyth 9/21 |
| Enloe | 4-0 | Home vs Sanderson 9/21 |
| Fuquay-Varina | 4-0 | Home vs Knightdale 9/21 |
| Hough | 4-0 | Away vs Hopewell 9/21 |
| Mooresville | 4-0 | Home vs North Mecklenburg 9/21 |
| Myers Park | 4-0 | Home vs Garinger 9/21 |
| North Mecklenburg | 4-0 | Away vs Mooresville 9/21 |
| South Central | 4-0 | Home vs J.H. Rose 9/21 |
| South View | 4-0 | Home vs Pine Forest 9/28 |
| Vance | 4-0 | At UNCC vs Mallard Creek 9/21 |
| Wake Forest | 4-0 | Away vs Franklinton 9/21 |
| Mallard Creek | 3-0 | At UNCC vs Vance 9/21 |
| Overhills | 3-0 | Away vs Terry Sanford 9/21 |
| 3A - 18 Teams | Next Game | |
| Franklinton | 5-0 | Home vs Wake Forest 9/21 |
| Parkland | 5-0 | Away vs Southwest Guilford 9/21 |
| Southern Alamance | 5-0 | Away vs Southwestern Randolph 9/21 |
| Southwest Guilford | 5-0 | Home vs Parkland 9/21 |
| Alexander Central | 4-0 | Home vs West Caldwell 9/21 |
| Central Cabarrus | 4-0 | Home vs Carson 9/21 |
| Havelock | 4-0 | Home vs Hunt 9/21 |
| Huss | 4-0 | Home vs North Gaston 9/21 |
| Lee County | 4-0 | Away vs Lee County 9/18 |
| Northern Durham | 4-0 | Away vs Southern Durham 9/21 |
| Northwest Cabarrus | 4-0 | Away vs East Rowan 9/21 |
| Southern Nash | 4-0 | Away vs White Oak 9/21 |
| Sun Valley | 4-0 | Home vs Weddington 9/21 |
| Topsail | 4-0 | Away vs Hoggard 9/21 |
| Watauga | 4-0 | Away vs South Caldwell 9/21 |
| Weddington | 4-0 | Away vs Sun Valley 9/21 |
| Jacksonville | 3-0 | Home vs Hertford 9/28 |
| Rocky Mount | 3-0 | Away vs Nash Central 9/21 |
| 2A - 17 Teams | Next Game | |
| East Rutherford | 5-0 | Away vs Polk 9/28 |
| Eastern Randolph | 5-0 | Away vs Providence Grove 9/21 |
| Hibriten | 5-0 | Home vs Bunker Hill 9/21 |
| Reidsville | 5-0 | Away vs Northwest Guilford 9/21 |
| Wheatmore | 5-0 | Home vs Randleman 9/21 |
| Currituck County | 4-0 | Away vs SouthWest Edgecome 9/28 |
| Kinston | 4-0 | Home vs South Lenoir 9/21 |
| Maiden | 4-0 | Away vs Bandys 9/21 |
| North Wilkes | 4-0 | Away vs East Wilkes 9/21 |
| Randleman | 4-0 | Away vs Wheatmore 9/21 |
| South Granville | 4-0 | Home vs Louisburg 9/21 |
| Carrboro | 3-0 | Away vs East Wake 9/21 |
| Northeastern | 3-0 | Away vs Holmes 9/21 |
| Smoky Mountain | 3-0 | Home vs Tuscola 9/21 |
| South Columbus | 3-0 | Home vs West Columbus 9/21 |
| St Pauls | 3-0 | Away vs Fairmont 9/21 |
| West Lincoln | 3-0 | Away vs North Lincoln 9/21 |
| 1A - 10 Teams | Next Game | |
| Mount Airy | 5-0 | Home vs Surry Central 9/21 |
| Holmes | 4-0 | Home vs Northeastern 9/21 |
| Lakewood | 4-0 | Away vs Western Harnett 9/21 |
| Tarboro | 4-0 | Away vs South Creek 9/21 |
| Thomas Jefferson | 4-0 | Home vs Cherryville 9/21 |
| Gates County | 3-0 | Home vs Pasquotank 9/21 |
| Granville Central | 3-0 | Away vs Warren County 9/21 |
| Highland Tech | 3-0 | Home vs Comm Sch of Davidson 9/21 |
| Pamlico | 3-0 | Home vs Northside-Pinetown 9/21 |
| Princeton | 3-0 | Away vs North Johnston 9/21 |
